HIF-1BETA COPS5 COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)|8q13 Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Hydroxylates HIF-1 alpha at Asp-803 in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases Part of a complex with VHL, HIF1A and HDAC1 or HDAC2 or HDAC3. Hydroxylates HIF-1 alpha at Asp-803 in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases P53 RNF53 CDKN2A