In addition to the computational predicted interactions produced in our Lab, Predictome database also collects experimentally determined ones by either directly importing from literatures, or by synchronizing with existing interaction databases such as Biogrid, MINT,  BIND, MIPS, IntAct, HPRD etc. The integration of the interaction is gene-based, meaning that two protein nodes will be recognized as a single protein, if the same gene encodes them. This decision not to distinguish gene nodes from protein nodes was based primarily on the following observations:
Because genes often encode multiple proteins, using gene id to represent both gene and protein is a natural choice; otherwise, uncertainty may arise when integrating interaction data. For example, for a gene with two splice variants, the variant to use when integrating interactions between the MINT (protein-based) and Biogrid databases (gene-based) will be ambiguous. The shortcoming of this solution is that certain splice variants may only share a subset of interactions. This dilemma can be overcome if alternative splicing knowledge is represented using a metanode, an undergoing process of this project.


Summary
Total*:1359532 Computational predicted:300290 Experimental determined:1059242
Species Supported:112
Aeropyrum pernix:3355  (5.31) Agrobacterium tumefaciens strain C58 (Cereon):11802  (8.26)
Akodon aerosus:83  (4.61) Aquifex aeolicus:2817  (3.81)
Arabidopsis thaliana:171329  (13.34) Archaeoglobus fulgidus:4328  (3.99)
Artocarpus heterophyllus:2  (0.67) Azotobacter vinelandii:8  (1.33)
Bacillus halodurans:6059  (3.75) Bacillus subtilis:7542  (3.96)
Borrelia burgdorferi:1866  (4.74) Bos taurus:533  (1.26)
Brucella melitensis:4482  (4.87) Buchnera sp. APS:1529  (3.65)
Caenorhabditis elegans:16626  (2.35) Campylobacter jejuni:4309  (4.59)
Candida albicans:5  (1) Canis lupus familiaris:32  (0.82)
Caulobacter crescentus:5910  (4.21) Chlamydia pneumoniae:1589  (3.83)
Chlamydia trachomatis:1539  (3.91) Chlamydomonas reinhardtii:60  (1.36)
Clostridium acetobutylicum:3404  (4.93) Corynebacterium glutamicum:2433  (4.33)
Danio rerio:255  (1.19) Deinococcus radiodurans:3954  (3.33)
Desulfovibrio desulfuricans:4  (0.5) Drosophila melanogaster:52000  (5.69)
Encephalitozoon_cuniculi:3788  (21.65) Enterobacteria phage:45  (0.83)
Enterobacteria phage PRD1:1  (1) Escherichia coli K-12:27435  (7.27)
Escherichia coli O157:8029  (3.32) Escherichia coli O157:H7:7498  (5.25)
Fusobacterium nucleatum:1941  (4.39) Gallus gallus:567  (1.42)
Geobacillus stearothermophilus:14  (0.58) Haemophilus influenzae:3196  (2.93)
Haloarcula marismortui:5  (0.62) Halobacterium sp. NRC-1:4582  (5.94)
Helicobacter pylori 26695:4491  (4.08) Helicobacter pylori J99:2591  (3.8)
Hepatitis C virus:2  (2) Homo sapiens:307353  (17.18)
Human herpesvirus 3:38  (1.65) Human herpesvirus 8:35  (1.46)
Human immunodeficiency virus:52  (0.72) Human immunodeficiency virus 1:33  (1.18)
Human papillomavirus type 16:4  (1) Influenza A virus:14  (1)
Klebsiella pneumoniae:10  (0.83) Kluyveromyces lactis:2  (1)
Lactococcus lactis:2668  (2.96) Listeria innocua:3819  (4.91)
Mesorhizobium loti:15959  (5.96) Methanocaldococcus jannaschii:3276  (4.63)
Methanopyrus kandleri AV19:2696  (7.64) Methanosarcina acetivorans str.C2A:3445  (6.6)
Methanothermobacter thermautotrophicus:3739  (4.13) Mus musculus:32770  (3.75)
Mycobacterium leprae:1860  (3.44) Mycobacterium tuberculosis:7890  (4.51)
Mycobacterium tuberculosis CDC1551:2856  (4.73) Mycoplasma genitalium:1011  (4)
Mycoplasma pneumoniae:1819  (3.61) Mycoplasma pulmonis:979  (5.56)
Neisseria meningitidis MC58:2938  (3.21) Neisseria meningitidis Z2491:2614  (3.12)
Neurospora crassa:17  (1.21) Nostoc sp. PCC 7120:4524  (5.23)
Oryctolagus cuniculus:81  (0.92) Oryza sativa:450  (1.07)
Pan troglodytes:1  (1) Paracoccus denitrificans:6  (0.67)
Pasteurella multocida:3390  (2.82) Pisum sativum:3  (0.6)
Plasmodium falciparum:2627  (2.06) Pseudomonas aeruginosa:18860  (6.42)
Pseudomonas putida:14  (0.7) Pyrobaculum aerophilum:3016  (7.54)
Pyrococcus abyssi:3444  (4.21) Pyrococcus furiosus:6  (0.5)
Pyrococcus horikoshii:3317  (4.24) Ralstonia solanacearum:7476  (5.89)
Rattus norvegicus:6667  (2.4) Rhodobacter sphaeroides:1  (1)
Rickettsia conorii:1662  (5.05) Rickettsia prowazekii:1711  (3.86)
Rickettsia sibirica 246:116  (1.18) Saccharomyces cerevisiae:391892  (60.4)
Salmonella typhimurium LT2:5681  (4.59) Schizosaccharomyces pombe:68940  (16.3)
Sinorhizobium meliloti:13455  (8.42) Staphylococcus aureus:12  (0.57)
Staphylococcus aureus N315:2699  (4.47) Streptococcus pneumoniae TIGR4:2455  (4.82)
Streptococcus pyogenes:2232  (2.92) Sulfolobus solfataricus:3060  (6.34)
Sus scrofa:82  (0.77) Synechocystis:7521  (6.24)
synthetic construct:23  (0.58) Thermoplasma acidophilum:2903  (5.34)
Thermoplasma volcanium:2959  (5.06) Thermotoga maritima:3319  (3.3)
Thermus aquaticus:3  (0.5) Thermus thermophilus:68  (0.73)
Treponema pallidum:3125  (4.83) Ureaplasma urealyticum:1030  (3.76)
Vibrio cholerae:10779  (5.24) Xenopus laevis:672  (1.52)
Xylella fastidiosa:3734  (3.36) Yersinia pestis:5603  (5.15)
Aeropyrum pernix
cosedimentation(M0033):1 domain fusion(M0036):126
gene neighbourhoods(M0038):271 molecular sieving(M0018):1
phylogenetic profile(M0037):2956 x-ray crystallography(M0071):1
Agrobacterium tumefaciens strain C58 (Cereon)
phylogenetic profile(M0037):11802
Akodon aerosus
affinity technology(M0045):13 two hybrid test(M0034):70
Aquifex aeolicus
domain fusion(M0036):282 gene neighbourhoods(M0038):206
molecular sieving(M0018):1 phylogenetic profile(M0037):2327
structure based prediction(M0048):2 x-ray crystallography(M0071):1
Arabidopsis thaliana
affinity technology(M0045):4540 anti bait coimmunoprecipitation(M0089):186
anti tag coimmunoprecipitation(M0065):1034 Biochemical Activity(M0083):391
blue native page(M0096):79 Chromatin Immunoprecipitation (ChIP)(M0042):1
chromatography technology(M0085):169 Co-fractionation(M0079):108
coimmunoprecipitation(M0010):273 colocalization/visualisation technologies(M0063):6
comigration in non denaturing gel electrophoresis(M0097):2 confocal microscopy(M0094):89
copurification(M0013):43 cosedimentation(M0033):24
cross-linking studies(M0014):14 Dosage Growth Defect(M0082):3
Dosage Rescue(M0077):1 electron microscopy(M0062):10
electrophoretic mobility shift assay(M0098):10 elisa:enzyme-linked immunosorbent assay(M0051):1
enzymatic study(M0066):64 far western blotting(M0060):54
filter binding(M0053):20 fluorescence technology(M0052):501
Gel retardation assays (M0019):2 genetic,synthetic growth effect(M0055):10
Invitro(M0084):294 isothermal titration calorimetry(M0103):7
mass spectrometry studies of complexes(M0028):19 molecular sieving(M0018):72
nuclear magnetic resonance(M0070):4 Other Biophysical(M0031):95
peptide array(M0092):1 phage display(M0050):100
Phenotypic Enhancement(M0075):47 Phenotypic Suppression(M0080):51
phosphatase assay(M0101):7 Predicted Arabidopsis molecular interactions (PAIR)(M0106):145841
protein array(M0068):664 protein complementation assay(M0069):35
protein kinase assay(M0095):102 Protein-RNA(M0078):4
pull down(M0067):752 Reconstituted Complex(M0074):989
resonance energy transfer(M0061):42 structure based prediction(M0048):34
surface plasmon resonance(M0049):10 Synthetic Rescue(M0081):4
tandem affinity purification(M0088):984 two hybrid test(M0034):13461
ubiquitin reconstruction(M0100):71 x-ray crystallography(M0071):16
Archaeoglobus fulgidus
domain fusion(M0036):798 gene neighbourhoods(M0038):462
molecular sieving(M0018):1 phylogenetic profile(M0037):3056
pull down(M0067):1 structure based prediction(M0048):9
x-ray crystallography(M0071):2
Artocarpus heterophyllus
structure based prediction(M0048):2
Azotobacter vinelandii
resonance energy transfer(M0061):1 structure based prediction(M0048):7
Bacillus halodurans
gene neighbourhoods(M0038):833 phylogenetic profile(M0037):5225
structure based prediction(M0048):1 x-ray crystallography(M0071):1
Bacillus subtilis
domain fusion(M0036):2213 gene neighbourhoods(M0038):812
phylogenetic profile(M0037):4489 structure based prediction(M0048):29
Borrelia burgdorferi
domain fusion(M0036):41 gene neighbourhoods(M0038):203
phylogenetic profile(M0037):1620 structure based prediction(M0048):2
Bos taurus
affinity technology(M0045):57 anti bait coimmunoprecipitation(M0089):63
Biochemical Activity(M0083):18 blue native page(M0096):1
chromatography technology(M0085):95 Co-fractionation(M0079):2
coimmunoprecipitation(M0010):13 comigration in non denaturing gel electrophoresis(M0097):1
copurification(M0013):1 cosedimentation(M0033):30
cross-linking studies(M0014):6 electron microscopy(M0062):3
enzymatic study(M0066):4 far western blotting(M0060):2
filter binding(M0053):1 fluorescence technology(M0052):6
imaging techniques(M0072):1 isothermal titration calorimetry(M0103):1
mass spectrometry studies of complexes(M0028):2 molecular sieving(M0018):15
nuclear magnetic resonance(M0070):2 Other Biophysical(M0031):20
protein kinase assay(M0095):2 pull down(M0067):28
Reconstituted Complex(M0074):13 resonance energy transfer(M0061):2
structure based prediction(M0048):116 surface plasmon resonance(M0049):2
two hybrid test(M0034):10 x-ray crystallography(M0071):21
Brucella melitensis
phylogenetic profile(M0037):4482
Buchnera sp. APS
gene neighbourhoods(M0038):241 phylogenetic profile(M0037):1288
Caenorhabditis elegans
affinity technology(M0045):543 anti bait coimmunoprecipitation(M0089):90
anti tag coimmunoprecipitation(M0065):179 Biochemical Activity(M0083):23
blue native page(M0096):1 chromatography technology(M0085):36
Co-fractionation(M0079):5 coimmunoprecipitation(M0010):89
colocalization by immunostaining(M0025):1 colocalization/visualisation technologies(M0063):12
Competition binding(M0012):3 confocal microscopy(M0094):26
copurification(M0013):3 cosedimentation(M0033):3
Dosage Rescue(M0077):5 electron microscopy(M0062):2
enzymatic study(M0066):6 far western blotting(M0060):19
fluorescence technology(M0052):54 Gel retardation assays (M0019):4
genetic,synthetic growth effect(M0055):3 imaging techniques(M0072):7
isothermal titration calorimetry(M0103):2 molecular sieving(M0018):20
Negative Genetic(M0104):1242 nuclear magnetic resonance(M0070):1
Other Biophysical(M0031):38 Phenotypic Enhancement(M0075):893
Phenotypic Suppression(M0080):68 protein complementation assay(M0069):4
protein kinase assay(M0095):13 Protein-RNA(M0078):3
pull down(M0067):123 Reconstituted Complex(M0074):82
resonance energy transfer(M0061):1 structure based prediction(M0048):10
surface plasmon resonance(M0049):5 Synthetic Rescue(M0081):112
tandem affinity purification(M0088):128 two hybrid test(M0034):12765
x-ray crystallography(M0071):6
Campylobacter jejuni
domain fusion(M0036):230 gene neighbourhoods(M0038):322
molecular sieving(M0018):1 phylogenetic profile(M0037):2558
structure based prediction(M0048):4 two hybrid test(M0034):1195
x-ray crystallography(M0071):1
Candida albicans
molecular sieving(M0018):1 structure based prediction(M0048):1
two hybrid test(M0034):3
Canis lupus familiaris
affinity technology(M0045):13 anti bait coimmunoprecipitation(M0089):3
coimmunoprecipitation(M0010):1 colocalization/visualisation technologies(M0063):2
confocal microscopy(M0094):2 cosedimentation(M0033):1
cross-linking studies(M0014):1 fluorescence technology(M0052):2
molecular sieving(M0018):1 Other Biophysical(M0031):1
pull down(M0067):2 Reconstituted Complex(M0074):2
resonance energy transfer(M0061):1 structure based prediction(M0048):2
two hybrid test(M0034):1
Caulobacter crescentus
anti tag coimmunoprecipitation(M0065):1 cross-linking studies(M0014):2
enzymatic study(M0066):1 gene neighbourhoods(M0038):565
molecular sieving(M0018):1 phylogenetic profile(M0037):5339
protein kinase assay(M0095):1
Chlamydia pneumoniae
domain fusion(M0036):103 gene neighbourhoods(M0038):171
phylogenetic profile(M0037):1315
Chlamydia trachomatis
cross-linking studies(M0014):1 domain fusion(M0036):57
gene neighbourhoods(M0038):167 phylogenetic profile(M0037):1313
protein complementation assay(M0069):1 two hybrid test(M0034):1
x-ray crystallography(M0071):1
Chlamydomonas reinhardtii
affinity technology(M0045):11 anti bait coimmunoprecipitation(M0089):21
anti tag coimmunoprecipitation(M0065):1 Biochemical Activity(M0083):6
cosedimentation(M0033):1 cross-linking studies(M0014):1
far western blotting(M0060):1 fluorescence technology(M0052):2
nuclear magnetic resonance(M0070):1 pull down(M0067):8
structure based prediction(M0048):6 x-ray crystallography(M0071):1
Clostridium acetobutylicum
phylogenetic profile(M0037):3403 structure based prediction(M0048):1
Corynebacterium glutamicum
blue native page(M0096):1 cross-linking studies(M0014):1
electron microscopy(M0062):1 molecular sieving(M0018):1
phylogenetic profile(M0037):2427 protein complementation assay(M0069):1
pull down(M0067):1 structure based prediction(M0048):1
surface plasmon resonance(M0049):1 x-ray crystallography(M0071):1
Danio rerio
affinity technology(M0045):56 anti bait coimmunoprecipitation(M0089):25
Biochemical Activity(M0083):5 coimmunoprecipitation(M0010):3
Dosage Rescue(M0077):1 fluorescence technology(M0052):2
Gel retardation assays (M0019):1 Other Biophysical(M0031):1
Phenotypic Enhancement(M0075):43 Phenotypic Suppression(M0080):23
pull down(M0067):1 Reconstituted Complex(M0074):13
solid phase assay(M0102):1 structure based prediction(M0048):1
two hybrid test(M0034):80 x-ray crystallography(M0071):1
Deinococcus radiodurans
domain fusion(M0036):1204 gene neighbourhoods(M0038):415
molecular sieving(M0018):1 Other Biophysical(M0031):1
phylogenetic profile(M0037):2331 structure based prediction(M0048):3
x-ray crystallography(M0071):1
Desulfovibrio desulfuricans
structure based prediction(M0048):4
Drosophila melanogaster
affinity technology(M0045):12833 anti bait coimmunoprecipitation(M0089):216
anti tag coimmunoprecipitation(M0065):4231 Biochemical Activity(M0083):86
chromatography technology(M0085):19 Co-fractionation(M0079):52
coimmunoprecipitation(M0010):139 colocalization by immunostaining(M0025):2
colocalization/visualisation technologies(M0063):18 comigration in non denaturing gel electrophoresis(M0097):5
Competition binding(M0012):11 confocal microscopy(M0094):9
copurification(M0013):59 cosedimentation(M0033):227
cross-linking studies(M0014):14 Dosage Rescue(M0077):8
electron microscopy(M0062):9 electrophoretic mobility shift assay(M0098):2
elisa:enzyme-linked immunosorbent assay(M0051):4 enzymatic study(M0066):7
far western blotting(M0060):20 filter binding(M0053):2
fluorescence technology(M0052):89 Gel retardation assays (M0019):8
genetic,synthetic growth effect(M0055):3 genetic,synthetic lethality(M0047):2
imaging techniques(M0072):20 isothermal titration calorimetry(M0103):8
molecular sieving(M0018):32 Negative Genetic(M0104):1
nuclear magnetic resonance(M0070):4 Other Biophysical(M0031):901
phage display(M0050):14 Phenotypic Enhancement(M0075):1418
Phenotypic Suppression(M0080):1830 phosphatase assay(M0101):2
protein complementation assay(M0069):3 protein kinase assay(M0095):17
Protein-RNA(M0078):1 pull down(M0067):4182
Reconstituted Complex(M0074):260 resonance energy transfer(M0061):2
solid phase assay(M0102):37 structure based prediction(M0048):31
surface plasmon resonance(M0049):15 Synthetic Haploinsufficiency(M0086):2
Synthetic Rescue(M0081):18 tandem affinity purification(M0088):66
two hybrid test(M0034):25052 western blot(M0021):1
x-ray crystallography(M0071):16
Encephalitozoon_cuniculi
phylogenetic profile(M0037):3788
Enterobacteria phage
cross-linking studies(M0014):1 electron microscopy(M0062):1
molecular sieving(M0018):1 structure based prediction(M0048):4
two hybrid test(M0034):38 x-ray crystallography(M0071):2
Enterobacteria phage PRD1
structure based prediction(M0048):1
Escherichia coli K-12
affinity technology(M0045):82 anti bait coimmunoprecipitation(M0089):4
anti tag coimmunoprecipitation(M0065):1775 Biochemical Activity(M0083):92
blue native page(M0096):6 chromatography technology(M0085):119
coimmunoprecipitation(M0010):112 colocalization by immunostaining(M0025):1
comigration in non denaturing gel electrophoresis(M0097):62 cosedimentation(M0033):92
cross-linking studies(M0014):231 domain fusion(M0036):2697
electron microscopy(M0062):36 elisa:enzyme-linked immunosorbent assay(M0051):2
enzymatic study(M0066):18 far western blotting(M0060):12
filter binding(M0053):4 fluorescence technology(M0052):14
Gel retardation assays (M0019):42 gene neighbourhoods(M0038):1017
inferred by author(M0091):5992 isothermal titration calorimetry(M0103):7
mass spectrometry studies of complexes(M0028):31 molecular sieving(M0018):172
nuclear magnetic resonance(M0070):14 Other Biophysical(M0031):102
Phenotypic Enhancement(M0075):4 phosphatase assay(M0101):2
phylogenetic profile(M0037):5127 protein complementation assay(M0069):119
protein kinase assay(M0095):3 pull down(M0067):61
Reconstituted Complex(M0074):1 resonance energy transfer(M0061):8
structure based prediction(M0048):801 surface plasmon resonance(M0049):46
tandem affinity purification(M0088):8251 two hybrid test(M0034):144
x-ray crystallography(M0071):137
Escherichia coli O157
gene neighbourhoods(M0038):1295 phylogenetic profile(M0037):6734
Escherichia coli O157:H7
anti tag coimmunoprecipitation(M0065):596 blue native page(M0096):1
cosedimentation(M0033):1 electron microscopy(M0062):1
elisa:enzyme-linked immunosorbent assay(M0051):1 molecular sieving(M0018):4
Other Biophysical(M0031):3 phylogenetic profile(M0037):6881
pull down(M0067):7 two hybrid test(M0034):1
x-ray crystallography(M0071):4
Fusobacterium nucleatum
Biochemical Activity(M0083):1 phylogenetic profile(M0037):1940
x-ray crystallography(M0071):1
Gallus gallus
affinity technology(M0045):264 anti bait coimmunoprecipitation(M0089):91
anti tag coimmunoprecipitation(M0065):17 Biochemical Activity(M0083):6
chromatography technology(M0085):3 Co-fractionation(M0079):3
coimmunoprecipitation(M0010):16 colocalization by immunostaining(M0025):2
colocalization/visualisation technologies(M0063):3 confocal microscopy(M0094):3
copurification(M0013):4 cosedimentation(M0033):3
cross-linking studies(M0014):7 electron microscopy(M0062):1
elisa:enzyme-linked immunosorbent assay(M0051):1 far western blotting(M0060):2
fluorescence technology(M0052):7 Gel retardation assays (M0019):4
genetic,synthetic growth effect(M0055):2 genetic,synthetic lethality(M0047):1
molecular sieving(M0018):8 Other Biophysical(M0031):8
phage display(M0050):2 Phenotypic Enhancement(M0075):4
protein kinase assay(M0095):2 pull down(M0067):13
Reconstituted Complex(M0074):20 solid phase assay(M0102):2
structure based prediction(M0048):50 surface plasmon resonance(M0049):1
transient coexpression(M0039):1 two hybrid test(M0034):8
x-ray crystallography(M0071):12
Geobacillus stearothermophilus
Other Biophysical(M0031):2 structure based prediction(M0048):13
Haemophilus influenzae
cross-linking studies(M0014):1 domain fusion(M0036):194
gene neighbourhoods(M0038):527 molecular sieving(M0018):1
phylogenetic profile(M0037):2424 structure based prediction(M0048):48
x-ray crystallography(M0071):2
Haloarcula marismortui
structure based prediction(M0048):5
Halobacterium sp. NRC-1
gene neighbourhoods(M0038):327 phylogenetic profile(M0037):4255
Helicobacter pylori 26695
cosedimentation(M0033):1 domain fusion(M0036):202
gene neighbourhoods(M0038):233 molecular sieving(M0018):3
Other Biophysical(M0031):1435 phylogenetic profile(M0037):2267
pull down(M0067):6 structure based prediction(M0048):1
two hybrid test(M0034):343 x-ray crystallography(M0071):3
Helicobacter pylori J99
blue native page(M0096):28 cosedimentation(M0033):1
domain fusion(M0036):132 gene neighbourhoods(M0038):235
molecular sieving(M0018):1 Other Biophysical(M0031):1
phylogenetic profile(M0037):2193 x-ray crystallography(M0071):1
Hepatitis C virus
coimmunoprecipitation(M0010):1 structure based prediction(M0048):1
two hybrid test(M0034):1
Homo sapiens
affinity technology(M0045):90542 anti bait coimmunoprecipitation(M0089):13346
anti tag coimmunoprecipitation(M0065):16737 Biochemical Activity(M0083):6053
blue native page(M0096):165 Chromatin Immunoprecipitation (ChIP)(M0042):751
chromatography technology(M0085):1121 Co-fractionation(M0079):21185
coimmunoprecipitation(M0010):4601 colocalization by immunostaining(M0025):225
colocalization/visualisation technologies(M0063):1405 comigration in non denaturing gel electrophoresis(M0097):80
Competition binding(M0012):95 confocal microscopy(M0094):650
copurification(M0013):1396 cosedimentation(M0033):843
cross-linking studies(M0014):3866 dihydrofolate reductase reconstruction(M0090):6
Dosage Lethality(M0076):102 Dosage Rescue(M0077):6
electron microscopy(M0062):97 electrophoretic mobility shift assay(M0098):19
elisa:enzyme-linked immunosorbent assay(M0051):204 enzymatic study(M0066):511
far western blotting(M0060):817 filter binding(M0053):214
fluorescence technology(M0052):2025 Gel retardation assays (M0019):28
genetic,synthetic growth effect(M0055):15 genetic,synthetic lethality(M0047):1
imaging techniques(M0072):244 inferred by author(M0091):3
Invitro(M0084):19277 Invivo(M0073):17852
isothermal titration calorimetry(M0103):290 mass spectrometry studies of complexes(M0028):38
molecular sieving(M0018):767 Negative Genetic(M0104):605
nuclear magnetic resonance(M0070):268 Other Biophysical(M0031):2406
other genetic(M0030):27 peptide array(M0092):1102
phage display(M0050):138 Phenotypic Enhancement(M0075):177
Phenotypic Suppression(M0080):157 phosphatase assay(M0101):268
Positive Genetic(M0105):271 protein array(M0068):725
protein complementation assay(M0069):319 protein kinase assay(M0095):993
Protein-RNA(M0078):205 pull down(M0067):6737
Reconstituted Complex(M0074):18952 resonance energy transfer(M0061):139
solid phase assay(M0102):45 structure based prediction(M0048):1186
surface plasmon resonance(M0049):500 Synthetic Rescue(M0081):8
tandem affinity purification(M0088):5564 TFSVM (Predicted TF by SVM)(M0064):11247
transient coexpression(M0039):1 two hybrid test(M0034):48762
ubiquitin reconstruction(M0100):281 western blot(M0021):1
x-ray crystallography(M0071):710
Human herpesvirus 3
affinity technology(M0045):1 structure based prediction(M0048):1
two hybrid test(M0034):37
Human herpesvirus 8
anti tag coimmunoprecipitation(M0065):14 Other Biophysical(M0031):1
two hybrid test(M0034):20
Human immunodeficiency virus
affinity technology(M0045):2 coimmunoprecipitation(M0010):1
cosedimentation(M0033):1 cross-linking studies(M0014):2
Other Biophysical(M0031):2 resonance energy transfer(M0061):1
structure based prediction(M0048):45 two hybrid test(M0034):1
Human immunodeficiency virus 1
affinity technology(M0045):9 Biochemical Activity(M0083):1
coimmunoprecipitation(M0010):2 cosedimentation(M0033):1
cross-linking studies(M0014):1 fluorescence technology(M0052):2
Other Biophysical(M0031):1 Reconstituted Complex(M0074):2
resonance energy transfer(M0061):1 structure based prediction(M0048):14
two hybrid test(M0034):2
Human papillomavirus type 16
coimmunoprecipitation(M0010):1 cosedimentation(M0033):1
nuclear magnetic resonance(M0070):1 pull down(M0067):1
two hybrid test(M0034):2
Influenza A virus
structure based prediction(M0048):14
Klebsiella pneumoniae
structure based prediction(M0048):10
Kluyveromyces lactis
molecular sieving(M0018):1 x-ray crystallography(M0071):1
Lactococcus lactis
gene neighbourhoods(M0038):412 Other Biophysical(M0031):2
phylogenetic profile(M0037):2253 structure based prediction(M0048):2
Listeria innocua
phylogenetic profile(M0037):3818 structure based prediction(M0048):1
Mesorhizobium loti
gene neighbourhoods(M0038):1185 phylogenetic profile(M0037):14773
structure based prediction(M0048):1
Methanocaldococcus jannaschii
blue native page(M0096):1 chromatography technology(M0085):1
cosedimentation(M0033):3 domain fusion(M0036):299
electron microscopy(M0062):5 gene neighbourhoods(M0038):205
molecular sieving(M0018):3 nuclear magnetic resonance(M0070):1
Other Biophysical(M0031):1 phylogenetic profile(M0037):2738
pull down(M0067):4 structure based prediction(M0048):11
two hybrid test(M0034):1 x-ray crystallography(M0071):5
Methanopyrus kandleri AV19
phylogenetic profile(M0037):2696
Methanosarcina acetivorans str.C2A
phylogenetic profile(M0037):3444 two hybrid test(M0034):1
Methanothermobacter thermautotrophicus
Biochemical Activity(M0083):1 blue native page(M0096):43
cosedimentation(M0033):1 domain fusion(M0036):591
fluorescence technology(M0052):3 Gel retardation assays (M0019):1
gene neighbourhoods(M0038):347 mass spectrometry studies of complexes(M0028):1
molecular sieving(M0018):2 Other Biophysical(M0031):2
phylogenetic profile(M0037):2728 structure based prediction(M0048):16
surface plasmon resonance(M0049):1 two hybrid test(M0034):2
x-ray crystallography(M0071):2
Mus musculus
affinity technology(M0045):9669 anti bait coimmunoprecipitation(M0089):2620
anti tag coimmunoprecipitation(M0065):2069 Biochemical Activity(M0083):483
blue native page(M0096):65 Chromatin Immunoprecipitation (ChIP)(M0042):467
chromatography technology(M0085):365 Co-fractionation(M0079):182
coimmunoprecipitation(M0010):1300 colocalization by immunostaining(M0025):36
colocalization/visualisation technologies(M0063):156 comigration in non denaturing gel electrophoresis(M0097):7
Competition binding(M0012):43 confocal microscopy(M0094):143
copurification(M0013):78 cosedimentation(M0033):6729
cross-linking studies(M0014):735 Dosage Rescue(M0077):5
electron microscopy(M0062):10 electrophoretic mobility shift assay(M0098):9
elisa:enzyme-linked immunosorbent assay(M0051):25 enzymatic study(M0066):46
far western blotting(M0060):106 filter binding(M0053):14
fluorescence technology(M0052):305 Gel retardation assays (M0019):17
genetic,synthetic growth effect(M0055):7 genetic,synthetic lethality(M0047):13
imaging techniques(M0072):73 inferred by author(M0091):1
isothermal titration calorimetry(M0103):36 mass spectrometry studies of complexes(M0028):3
molecular sieving(M0018):129 Negative Genetic(M0104):1
nuclear magnetic resonance(M0070):17 Other Biophysical(M0031):621
other genetic(M0030):8 peptide array(M0092):5
phage display(M0050):16 Phenotypic Enhancement(M0075):85
Phenotypic Suppression(M0080):92 phosphatase assay(M0101):6
protein array(M0068):1 protein complementation assay(M0069):4
protein kinase assay(M0095):32 Protein-RNA(M0078):5
pull down(M0067):1304 Reconstituted Complex(M0074):788
resonance energy transfer(M0061):20 solid phase assay(M0102):5
structure based prediction(M0048):370 surface plasmon resonance(M0049):66
Synthetic Haploinsufficiency(M0086):2 Synthetic Rescue(M0081):8
tandem affinity purification(M0088):205 transient coexpression(M0039):1
two hybrid test(M0034):3056 ubiquitin reconstruction(M0100):2
x-ray crystallography(M0071):115
Mycobacterium leprae
blue native page(M0096):1 gene neighbourhoods(M0038):220
molecular sieving(M0018):1 phylogenetic profile(M0037):1638
structure based prediction(M0048):1
Mycobacterium tuberculosis
affinity technology(M0045):4 anti tag coimmunoprecipitation(M0065):2
blue native page(M0096):1 comigration in non denaturing gel electrophoresis(M0097):2
cosedimentation(M0033):2 cross-linking studies(M0014):2
dihydrofolate reductase reconstruction(M0090):11 domain fusion(M0036):4292
fluorescence technology(M0052):1 gene neighbourhoods(M0038):574
isothermal titration calorimetry(M0103):3 molecular sieving(M0018):2
nuclear magnetic resonance(M0070):1 Other Biophysical(M0031):7
phylogenetic profile(M0037):2863 protein complementation assay(M0069):6
protein kinase assay(M0095):16 pull down(M0067):15
structure based prediction(M0048):56 surface plasmon resonance(M0049):4
two hybrid test(M0034):26 x-ray crystallography(M0071):5
Mycobacterium tuberculosis CDC1551
phylogenetic profile(M0037):2855 structure based prediction(M0048):1
Mycoplasma genitalium
domain fusion(M0036):24 gene neighbourhoods(M0038):131
phylogenetic profile(M0037):856
Mycoplasma pneumoniae
gene neighbourhoods(M0038):147 inferred by author(M0091):367
phylogenetic profile(M0037):791 structure based prediction(M0048):1
tandem affinity purification(M0088):514
Mycoplasma pulmonis
phylogenetic profile(M0037):979
Neisseria meningitidis MC58
domain fusion(M0036):222 gene neighbourhoods(M0038):339
phylogenetic profile(M0037):2377 structure based prediction(M0048):1
Neisseria meningitidis Z2491
gene neighbourhoods(M0038):345 phylogenetic profile(M0037):2269
Neurospora crassa
anti bait coimmunoprecipitation(M0089):1 cosedimentation(M0033):1
cross-linking studies(M0014):9 electron microscopy(M0062):1
enzymatic study(M0066):1 molecular sieving(M0018):1
Other Biophysical(M0031):1 tandem affinity purification(M0088):1
two hybrid test(M0034):2 x-ray crystallography(M0071):1
Nostoc sp. PCC 7120
molecular sieving(M0018):1 nuclear magnetic resonance(M0070):1
phylogenetic profile(M0037):4508 resonance energy transfer(M0061):1
structure based prediction(M0048):1 surface plasmon resonance(M0049):4
two hybrid test(M0034):8 x-ray crystallography(M0071):2
Oryctolagus cuniculus
affinity technology(M0045):13 anti bait coimmunoprecipitation(M0089):3
Biochemical Activity(M0083):3 chromatography technology(M0085):2
coimmunoprecipitation(M0010):3 comigration in non denaturing gel electrophoresis(M0097):1
copurification(M0013):1 cosedimentation(M0033):4
cross-linking studies(M0014):2 electron microscopy(M0062):4
enzymatic study(M0066):1 filter binding(M0053):3
fluorescence technology(M0052):1 Gel retardation assays (M0019):1
imaging techniques(M0072):1 isothermal titration calorimetry(M0103):1
molecular sieving(M0018):1 nuclear magnetic resonance(M0070):1
Other Biophysical(M0031):5 phage display(M0050):1
protein kinase assay(M0095):1 pull down(M0067):2
Reconstituted Complex(M0074):12 resonance energy transfer(M0061):1
structure based prediction(M0048):14 two hybrid test(M0034):1
x-ray crystallography(M0071):2
Oryza sativa
affinity technology(M0045):3 anti bait coimmunoprecipitation(M0089):8
anti tag coimmunoprecipitation(M0065):2 coimmunoprecipitation(M0010):2
cross-linking studies(M0014):2 enzymatic study(M0066):1
fluorescence technology(M0052):3 molecular sieving(M0018):4
nuclear magnetic resonance(M0070):1 protein kinase assay(M0095):1
pull down(M0067):7 structure based prediction(M0048):1
two hybrid test(M0034):415 x-ray crystallography(M0071):1
Pan troglodytes
structure based prediction(M0048):1
Paracoccus denitrificans
structure based prediction(M0048):6
Pasteurella multocida
gene neighbourhoods(M0038):690 phylogenetic profile(M0037):2700
Pisum sativum
cross-linking studies(M0014):1 structure based prediction(M0048):2
Plasmodium falciparum
anti bait coimmunoprecipitation(M0089):9 anti tag coimmunoprecipitation(M0065):3
Biochemical Activity(M0083):1 cosedimentation(M0033):1
enzymatic study(M0066):4 fluorescence technology(M0052):2
mass spectrometry studies of complexes(M0028):1 molecular sieving(M0018):3
protein kinase assay(M0095):3 structure based prediction(M0048):4
surface plasmon resonance(M0049):6 two hybrid test(M0034):2590
x-ray crystallography(M0071):2
Pseudomonas aeruginosa
Biochemical Activity(M0083):1 cross-linking studies(M0014):2
domain fusion(M0036):6577 enzymatic study(M0066):1
fluorescence technology(M0052):1 gene neighbourhoods(M0038):1382
molecular sieving(M0018):2 Other Biophysical(M0031):3
phylogenetic profile(M0037):10828 protein complementation assay(M0069):1
pull down(M0067):3 structure based prediction(M0048):53
two hybrid test(M0034):2 x-ray crystallography(M0071):5
Pseudomonas putida
structure based prediction(M0048):13 x-ray crystallography(M0071):1
Pyrobaculum aerophilum
phylogenetic profile(M0037):3015 structure based prediction(M0048):1
Pyrococcus abyssi
domain fusion(M0036):224 gene neighbourhoods(M0038):387
molecular sieving(M0018):1 Other Biophysical(M0031):1
phylogenetic profile(M0037):2824 pull down(M0067):5
structure based prediction(M0048):1 surface plasmon resonance(M0049):1
x-ray crystallography(M0071):1
Pyrococcus furiosus
coimmunoprecipitation(M0010):1 structure based prediction(M0048):5
Pyrococcus horikoshii
anti bait coimmunoprecipitation(M0089):2 domain fusion(M0036):231
fluorescence technology(M0052):1 gene neighbourhoods(M0038):307
molecular sieving(M0018):1 Other Biophysical(M0031):2
phylogenetic profile(M0037):2749 structure based prediction(M0048):8
two hybrid test(M0034):18
Ralstonia solanacearum
phylogenetic profile(M0037):7476
Rattus norvegicus
affinity technology(M0045):2438 anti bait coimmunoprecipitation(M0089):645
anti tag coimmunoprecipitation(M0065):675 Biochemical Activity(M0083):97
blue native page(M0096):7 Chromatin Immunoprecipitation (ChIP)(M0042):3
chromatography technology(M0085):7 Co-fractionation(M0079):57
coimmunoprecipitation(M0010):630 colocalization by immunostaining(M0025):19
colocalization/visualisation technologies(M0063):61 comigration in non denaturing gel electrophoresis(M0097):5
Competition binding(M0012):20 confocal microscopy(M0094):49
copurification(M0013):27 cosedimentation(M0033):92
cross-linking studies(M0014):34 electron microscopy(M0062):10
elisa:enzyme-linked immunosorbent assay(M0051):2 enzymatic study(M0066):8
far western blotting(M0060):65 filter binding(M0053):19
fluorescence technology(M0052):107 Gel retardation assays (M0019):3
imaging techniques(M0072):40 isothermal titration calorimetry(M0103):8
molecular sieving(M0018):20 nuclear magnetic resonance(M0070):8
Other Biophysical(M0031):147 other genetic(M0030):2
peptide array(M0092):2 phage display(M0050):4
Phenotypic Enhancement(M0075):1 Phenotypic Suppression(M0080):4
phosphatase assay(M0101):3 protein array(M0068):2
protein complementation assay(M0069):20 protein kinase assay(M0095):18
Protein-RNA(M0078):2 pull down(M0067):395
Reconstituted Complex(M0074):215 resonance energy transfer(M0061):22
solid phase assay(M0102):1 structure based prediction(M0048):105
surface plasmon resonance(M0049):14 two hybrid test(M0034):523
x-ray crystallography(M0071):40
Rhodobacter sphaeroides
structure based prediction(M0048):1
Rickettsia conorii
Other Biophysical(M0031):1 phylogenetic profile(M0037):1661
Rickettsia prowazekii
domain fusion(M0036):48 gene neighbourhoods(M0038):165
phylogenetic profile(M0037):1498
Rickettsia sibirica 246
two hybrid test(M0034):116
Saccharomyces cerevisiae
Affinity Column(M0006):33 Affinity Precipitation(M0044):63
affinity technology(M0045):62186 anti bait coimmunoprecipitation(M0089):389
anti tag coimmunoprecipitation(M0065):15526 Bayesian Predicted Interaction(M0046):15918
Biochemical Activity(M0083):5980 blue native page(M0096):52
Chromatin Immunoprecipitation (ChIP)(M0042):4370 chromatography technology(M0085):1986
Co-fractionation(M0079):863 coimmunoprecipitation(M0010):1739
colocalization by immunostaining(M0025):6 colocalization/visualisation technologies(M0063):548
comigration in non denaturing gel electrophoresis(M0097):91 Competition binding(M0012):9
confocal microscopy(M0094):14 copurification(M0013):2417
cosedimentation(M0033):298 cross-linking studies(M0014):275
dihydrofolate reductase reconstruction(M0090):2686 domain fusion(M0036):3017
Dosage Growth Defect(M0082):1911 Dosage Lethality(M0076):1584
Dosage Rescue(M0077):4440 electron microscopy(M0062):174
electrophoretic mobility shift assay(M0098):5 elisa:enzyme-linked immunosorbent assay(M0051):15
enzymatic study(M0066):51 far western blotting(M0060):105
filter binding(M0053):43 fluorescence technology(M0052):282
Gel retardation assays (M0019):34 gene neighbourhoods(M0038):9
genetic,conditional synthetic lethal(M0054):15 genetic suppression(M0058):210
genetic,suppression expression alteration(M0057):145 genetic,suppression mutation(M0056):39
genetic,synthetic growth effect(M0055):21509 genetic,synthetic lethality(M0047):13717
genetic synthetic phenotype(M0059):46 genetic,tetrad analysis(M0020):1318
imaging techniques(M0072):9 inferred by author(M0091):6626
In vitro binding(M0026):26 isothermal titration calorimetry(M0103):47
mass spectrometry studies of complexes(M0028):27 molecular sieving(M0018):399
Negative Genetic(M0104):88152 nuclear magnetic resonance(M0070):33
Other Biophysical(M0031):7376 other genetic(M0030):143
peptide array(M0092):384 phage display(M0050):18
Phenotypic Enhancement(M0075):5333 Phenotypic Suppression(M0080):4594
phosphatase assay(M0101):6 phylogenetic profile(M0037):8302
Positive Genetic(M0105):20966 protein array(M0068):533
protein complementation assay(M0069):38 protein kinase assay(M0095):240
Protein-RNA(M0078):535 pull down(M0067):2503
Reconstituted Complex(M0074):4648 resonance energy transfer(M0061):30
solid phase assay(M0102):5 structure based prediction(M0048):695
surface plasmon resonance(M0049):70 Synthetic Haploinsufficiency(M0086):283
Synthetic Rescue(M0081):5340 tandem affinity purification(M0088):49127
Transcription Factor(M0041):238 transient coexpression(M0039):98
two hybrid test(M0034):18696 ubiquitin reconstruction(M0100):2084
x-ray crystallography(M0071):189
Salmonella typhimurium LT2
affinity technology(M0045):1 chromatography technology(M0085):2
coimmunoprecipitation(M0010):2 cosedimentation(M0033):2
cross-linking studies(M0014):3 far western blotting(M0060):3
isothermal titration calorimetry(M0103):1 mass spectrometry studies of complexes(M0028):2
molecular sieving(M0018):3 Other Biophysical(M0031):2
peptide array(M0092):1 phylogenetic profile(M0037):5625
pull down(M0067):13 structure based prediction(M0048):15
two hybrid test(M0034):3 x-ray crystallography(M0071):5
Schizosaccharomyces pombe
affinity technology(M0045):7712 anti bait coimmunoprecipitation(M0089):17
anti tag coimmunoprecipitation(M0065):92 Biochemical Activity(M0083):231
chromatography technology(M0085):4 Co-fractionation(M0079):51
coimmunoprecipitation(M0010):49 colocalization/visualisation technologies(M0063):334
copurification(M0013):201 cosedimentation(M0033):3
cross-linking studies(M0014):8 Dosage Growth Defect(M0082):47
Dosage Lethality(M0076):82 Dosage Rescue(M0077):722
enzymatic study(M0066):4 far western blotting(M0060):28
fluorescence technology(M0052):9 genetic,synthetic growth effect(M0055):1879
genetic,synthetic lethality(M0047):860 isothermal titration calorimetry(M0103):3
molecular sieving(M0018):14 Negative Genetic(M0104):30455
Other Biophysical(M0031):39 Phenotypic Enhancement(M0075):1011
Phenotypic Suppression(M0080):970 phylogenetic profile(M0037):8122
Positive Genetic(M0105):13655 protein kinase assay(M0095):3
Protein-RNA(M0078):9 pull down(M0067):54
Reconstituted Complex(M0074):451 structure based prediction(M0048):39
surface plasmon resonance(M0049):1 Synthetic Rescue(M0081):760
tandem affinity purification(M0088):109 two hybrid test(M0034):909
x-ray crystallography(M0071):9
Sinorhizobium meliloti
phylogenetic profile(M0037):13453 structure based prediction(M0048):1
x-ray crystallography(M0071):1
Staphylococcus aureus
Other Biophysical(M0031):1 structure based prediction(M0048):10
x-ray crystallography(M0071):1
Staphylococcus aureus N315
molecular sieving(M0018):1 phylogenetic profile(M0037):2697
protein complementation assay(M0069):1 x-ray crystallography(M0071):1
Streptococcus pneumoniae TIGR4
affinity technology(M0045):132 coimmunoprecipitation(M0010):7
phylogenetic profile(M0037):2316 structure based prediction(M0048):1
Streptococcus pyogenes
gene neighbourhoods(M0038):354 phylogenetic profile(M0037):1871
structure based prediction(M0048):7
Sulfolobus solfataricus
cosedimentation(M0033):1 fluorescence technology(M0052):2
molecular sieving(M0018):1 phylogenetic profile(M0037):3043
structure based prediction(M0048):7 two hybrid test(M0034):2
x-ray crystallography(M0071):4
Sus scrofa
affinity technology(M0045):40 anti bait coimmunoprecipitation(M0089):1
anti tag coimmunoprecipitation(M0065):1 coimmunoprecipitation(M0010):2
confocal microscopy(M0094):1 cross-linking studies(M0014):1
molecular sieving(M0018):1 Other Biophysical(M0031):1
Reconstituted Complex(M0074):3 structure based prediction(M0048):27
two hybrid test(M0034):2 x-ray crystallography(M0071):3
Synechocystis
anti bait coimmunoprecipitation(M0089):1 blue native page(M0096):1
cosedimentation(M0033):1 domain fusion(M0036):4563
gene neighbourhoods(M0038):272 isothermal titration calorimetry(M0103):1
molecular sieving(M0018):3 phylogenetic profile(M0037):2663
pull down(M0067):2 structure based prediction(M0048):2
two hybrid test(M0034):12 x-ray crystallography(M0071):1
synthetic construct
structure based prediction(M0048):23
Thermoplasma acidophilum
gene neighbourhoods(M0038):216 molecular sieving(M0018):1
phylogenetic profile(M0037):2680 structure based prediction(M0048):5
x-ray crystallography(M0071):1
Thermoplasma volcanium
gene neighbourhoods(M0038):290 phylogenetic profile(M0037):2669
Thermotoga maritima
comigration in non denaturing gel electrophoresis(M0097):1 cosedimentation(M0033):1
cross-linking studies(M0014):2 domain fusion(M0036):529
gene neighbourhoods(M0038):473 phylogenetic profile(M0037):2256
structure based prediction(M0048):52 surface plasmon resonance(M0049):1
x-ray crystallography(M0071):4
Thermus aquaticus
structure based prediction(M0048):3
Thermus thermophilus
structure based prediction(M0048):68
Treponema pallidum
anti tag coimmunoprecipitation(M0065):3 domain fusion(M0036):54
gene neighbourhoods(M0038):203 phylogenetic profile(M0037):1698
structure based prediction(M0048):1 two hybrid test(M0034):1166
Ureaplasma urealyticum
domain fusion(M0036):32 gene neighbourhoods(M0038):141
phylogenetic profile(M0037):857
Vibrio cholerae
anti bait coimmunoprecipitation(M0089):1 Biochemical Activity(M0083):1
cosedimentation(M0033):1 domain fusion(M0036):4551
electron microscopy(M0062):1 gene neighbourhoods(M0038):1075
molecular sieving(M0018):1 phylogenetic profile(M0037):5131
protein complementation assay(M0069):2 pull down(M0067):2
structure based prediction(M0048):14 two hybrid test(M0034):2
x-ray crystallography(M0071):1
Xenopus laevis
affinity technology(M0045):269 anti bait coimmunoprecipitation(M0089):47
anti tag coimmunoprecipitation(M0065):25 Biochemical Activity(M0083):35
chromatography technology(M0085):6 Co-fractionation(M0079):22
coimmunoprecipitation(M0010):41 colocalization/visualisation technologies(M0063):7
comigration in non denaturing gel electrophoresis(M0097):1 Competition binding(M0012):2
copurification(M0013):1 cosedimentation(M0033):9
cross-linking studies(M0014):14 electron microscopy(M0062):2
enzymatic study(M0066):2 far western blotting(M0060):2
fluorescence technology(M0052):1 Gel retardation assays (M0019):1
imaging techniques(M0072):1 molecular sieving(M0018):4
nuclear magnetic resonance(M0070):1 Other Biophysical(M0031):7
Phenotypic Suppression(M0080):7 protein complementation assay(M0069):2
protein kinase assay(M0095):4 pull down(M0067):42
Reconstituted Complex(M0074):69 structure based prediction(M0048):19
tandem affinity purification(M0088):6 two hybrid test(M0034):26
x-ray crystallography(M0071):4
Xylella fastidiosa
domain fusion(M0036):357 gene neighbourhoods(M0038):528
molecular sieving(M0018):1 Other Biophysical(M0031):1
phylogenetic profile(M0037):2848
Yersinia pestis
phylogenetic profile(M0037):5602 structure based prediction(M0048):1


*This total number excludes the number of interactions extracts from the KEGG pathways; otherwise, the number shall >1M.